Typical chromatography-column design is 'axial' -wherein the chromatographic media (usually a resin) are packed in a flat, broad, pancake-like cylinder that is both extremely heavy and space-consuming. RFC, on the other hand, takes the horizontal chromatography cylinder and orients it vertically so that the media is wrapped around it, which reduces both the system’s footprint and weight while maintaining the high level of purification and fractionation of the API that is required.
A critical step in optimising the performance of an RFC column is the packing of the chromatography media (resin). Quattroflow pumps, available in QF-150, QF-1200, QF-4400, QF-5050 and QF20K sizes, are suited for this application because their four-piston/four-diaphragm method of design and operation delivers low pulsation, 'gentle' product handling, a large turndown ratio, high flow-rate accuracy, low noise and a compact construction.
All Quattroflow pump models also offer the option of single-use configurations with replaceable plastic heads, which eliminates the need for time-consuming cleaning between batches.
