Ecoprime low-pressure chromatography system.
Ecoprime low-pressure chromatography system.

From June 15-19, 2015, the Lewa team can be found at Achema in Hall 8.0, Stand C62.

Using the Ecoprime low-pressure chromatography system developed by Lewa GmbH, batch-to-batch reproducibility in GMP manufacturing of biopharmaceuticals can be enhanced significantly and the yield of the product can be enhanced.

Precise flow control

The system has been designed with an extremely precise flow control from 0.03 to 60 liters per minute, its dynamic flow rate range, minimal pulsation, and low holdup volume, aims at a better product yield, purity, and safety during purification. As a consequence, production time and the costs of validation in the entire production cycle are able to be reduced.

The pumps installed in the systems and registered for patent approval with the servo drive from Lewa allow high reproducibility of the adjustable parameters. Lewa claim that compared with other systems, a considerably higher accuracy over the entire flow rate range can also be covered with its Intellidrive technology.

Each Ecoprime system therefore offers an adjustment range of 1:150 or more. Because the Ecoprime system can handle the flow rate of up to three individual conventional process systems, investment costs and valuable floor space can be reduced, say Lewa. It is suited for use in cost-intensive GMP cleanrooms.


In the previous year, a license agreement with ChromaCon AG was sought to extend the Ecoprime batch chromatography platform, which applies to the use of Capture SMB technology, among others, at pilot and GMP scale for continuous purification. This allows various process principles such as batch or multi-column chromatography, Capture SMB, and MCSGP process principles to be undertaken with the same system platform. In addition, the contract between both companies enables them to further accelerate the development of modern cost-reducing purification processes for the manufacturers of biopharmaceuticals at GMP scale.